Latest news from the Beatty Research Group.

Dr. Miguel Macias Contreras has accepted a new position in Biotech, working as a research chemist at ION Biosciences.  This is an exciting opportunity for Miguel, allowing him to develop new fluorescent probes.  He will be missed, but we wish him the best of luck!

We are happy to welcome Kaylyn Devlin, PhD to the team!  Kaylyn is a key member of Team VIP.  She is collaborating with Dr. Jim Korkola to use VIP tags to image HER2/HER3 signaling in breast cancer cells.  

Congratulations to Dr. Sam Levine on her latest paper in ACS Infectious Diseases.  Her paper can be accessed online:

https://doi.org/10.1021/acsinfecdis.0c00809

Dr. Beatty has a new review out in Current Opinion in Chemical Biology: "Fluorescent Probes for Investigating Peptidoglycan Biosynthesis in Mycobacteria".  You can find this paper here:

https://authors.elsevier.com/a/1bCqb4sz6M8VsE

https://www.sciencedirect.com/science/article/pii/S1367593120300430?via%3Dihub

This review is part of a themed issue on Molecular Imaging, edited by Amy Palmer and Dan Yang.

 

Julia Doh will present her thesis research on Thursday April 30 at 1 pm.  This seminar will be held via WEBEX due to the pandemic.  The title of her talk is: "A peptide-based technology for tracking cellular proteins with multiscale microscopy".  Her thesis advisory committee members are: Francis Valiyaveetil (Chair), Caroline Enns, Carsten Schultz, Jim Korkola, Kimberly Beatty (PI), and Claudia Lopez.

 

UPDATE

Julia Doh passed her thesis exam!  Congratulations Dr. Doh!

Dr. Miguel Macias-Contreras has published a paper in Bioconjugate Chemistry (article link): "SNAP/CLIP-Tags and Strain-Promoted Azide-Alkyne Cycloaddition (SPAAC)/Inverse Electron Demand Diels-Alder (IEDDA) for Intracelullar Orthogonal/Bioorthogonal Labeling".  This is research that he did for this thesis with Lei Zhu at FSU.  Great work Miguel!

 

Congratulations to Savannah Tobin, former Beatty Lab member!  Savannah was awarded a fellowship to join the DVM/PhD program at UC Davis.  UC Davis has the #1 Vet program in the world!  We are so excited for Savannah!

OHSU has requested that basic researchers halt all non-critical wet-lab work to better enable the hospital to respond to the ongoing coronavirus pandemic.  In the Beatty lab, we were able to pause our experiments in March and are currently working from home.  Our first priority is to keep our friends, neighbors, and colleagues safe. We fortunately had N95 respirators in stock, which we gave to the hospital.  

We sincerely miss being at work, but are doing are best to accomplish goals from home.  For example, Julia is working hard to write up her dissertation.  The timeline to resume our lab work is unclear, but we look forward to getting back to it.  We are grateful to OHSU and Prof. Peter Barr-Gillespie (Chief Research Officer at OHSU) for keeping us updated and informed on the crisis and research impacts.   

--Kimberly Beatty (April 1, 2020)

A short perspective (by Kimberly Beatty)

I have been told many times that I "don't look like a scientist".  But what does a scientist look like?  To me, that is a strange question.  One could also ask, what does a doctor look like?  Or an author?  Or a teacher?  Or a chef?  Scientists are humans and, as such, we don't all look the same.  I have enjoyed working with dozens of scientists over the years, with varied backgrounds, hobbies, lifestyles, and interests.  I hope that we can celebrate and embrace our diversity, as well as our united passion for research.  

Cell Press published an article, "100 inspiring black scientists in America" (link here).  I invite you to visit this site to meet 100 talented scientists and learn more about what scientists look like.

Dr. Beatty attended PittCon 2020 in Chicago, IL to present in the session "Novel Probes for Visualizing Biochemical Processes in Cells, Tissues, and Tumor" chaired by John Ngo (BU).  Other talks were by: Allison Dennis (BU), Neal Devaraj (UCSD), and Bryan Dickinson (U Chicago).  It was a great session!

Dr. Beatty attended the Biophysical Society Meeting in San Diego (Feb. 2020).  She presented on VIP tags in a Tuesday evening Workshop chaired by Prof. Henry Colecraft ("Chemical Biology Tools for Biophysics").  The workshop also featured talks by: Ahern, Pless, Colecraft, and Sack.  

The BPS meeting featured an "Art of Science" Image contest, and Dr. Beatty loved the winning artwork (shown below), which was submitted by Fiona Naughton.  

OHSU hosted the "Chemical Biology and Physiology Conference 2019" in December.  This meeting, organized by Carsten Schultz and colleagues, is held every other year.  This year, the line-up of speakers was truly impressive.  Keynote talks were by Ben Cravatt, Laura Kiessling, and Tom Muir.  One of the Beatty group's favorite talks was by Alison Tebo (Sorbonne Universite, France).  We presented two posters, one on our VIP tags and another on Sam Levine's Mtb probes.  Such a great way to wrap up the year!

Julia Doh and coworkers prepared detailed methods papers for publication in Bio-protocol on using the VIPER tag.  We were interested in working with Bio-protocol and Editor Dr. Zhao Chen because this is an open-access journal.  We support Bio-protocol's mission, which is to "make life science research more efficient and reproducible by curating and hosting high quality, free access protocols".  You can find our methods papers in the current issue (Bio-protocol November 2019).