Kimberly Beatty (email: beattyk [at] ohsu)
Associate Professor, OHSU
UC Santa Barbara (B.S. in Biochemistry)
California Institute of Technology (Ph.D. in Chemistry, minor in Biology)
Walnut Creek, CA
Research Background and Interests:
As an undergraduate, I majored in Biochemistry at UC Santa Barbara. I entered college knowing that I wanted to be a scientist. In addition to taking classes, I had the opportunity to do research with Prof. Alison Butler on vanadium bromoperoxidases. Additionally, I did two internships off campus- at the UC Davis Medical Center and Genentech. These research experiences encouraged me to pursue a PhD in chemical biology, and I joined the graduate program in Chemistry at Caltech in 2002. In 2008, I completed my thesis research with Prof. David Tirrell. My studies there focused on developing novel methods for imaging subsets of cellular proteomes using azide-alkyne ligations (i.e., "click chemistry"). Next, I did a postdoc at UC Berkeley with Prof. Carolyn Bertozzi. In her group, I created a new approach towards studying enzyme biomarkers in tuberculosis using fluorogenic probes. Throughout my training, I was fortunate to work with brilliant, collaborative colleagues.
In 2012, I established my independent research program at Oregon Health & Science University in Portland, Oregon. My research program is focused on the development of chemical tools to understand the molecular basis of human diseases. Much of my research is disease-centered technology development, with an emphasis on studying tuberculosis (TB) and breast cancer. Together with my research team and collaborators, I have undertaken the following projects:
Project 1: Chemical tools for detecting hydrolase activities in Mycobacterium tuberculosis (Mtb).
Project 2: A new technology for tracking and mapping proteins by light and electron microscopy.
Project 3: Identifying molecular interactions that confer drug resistance in breast cancer.
Project 4: Synthesis of new fluorescent and fluorogenic probes.
My research findings have been published in various peer-reviewed journals. My most recent work can be found in: ChemBioChem, ACS Chemical Biology, Chemical Communications, and ACS Infectious Disease.
I have disseminated my research findings in various public forums. In April 2017, I presented my TB-focused research (Project 1) at the American Chemical Society (ACS) National meeting in San Francisco. In June 2017, I presented at the Bioorganic Chemistry GRC and in December 2017 I will present at Carsten Schultz's Chemical Biology Symposium at OHSU.
I have received generous funding support for my program from the Knight Cancer Institute, the OHSU School of Medicine, the Medical Research Foundation of Oregon, the Collins Medical Trust, and the National Institutes of Health (NIGMS R01 GM122854).
The most rewarding aspect of my career is working with all of my talented collaborators, including faculty members at OHSU (Korkola, Gray, Enns), the members of my team (Tallman, Levine, Zane, Doh, White, Naganbabu), and our summer interns (Marchando, Shelby, Janisse, Pillsbury, Orellana, Wallace).